C5 Antikörper (AA 19-294) (APC)

Produktnummer ABIN7981400

Der APC-konjugierte Kaninchen Polyklonal anti-C5 Antikörper (ABIN7981400) detektiert spezifisch C5 in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Maus.

Kurzübersicht für C5 Antikörper (AA 19-294) (APC) (ABIN7981400)

Target: C5 (Complement Component 5 (C5))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C5 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-C5 Antikörper (APC)

Bindungsspezifität: AA 19-294

Verwendungszweck: Anti-C5 Antibody APC Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived mouse C5 recombinant protein (Position: Q19-D294).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu C5

Target: C5 (Complement Component 5 (C5))

Andere Bezeichnung: C5

Hintergrund:

Background: Complement component 5 is a protein that in humans is encoded by the C5 gene. This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model.

Gene Full Name: hemolytic complement

Gen-ID: 15139

UniProt: P06684

Pathways: Komplementsystem, Carbohydrate Homeostasis