C6orf150 Antikörper (AA 352-504) (Biotin)

Produktnummer ABIN7980137

Der Biotin-konjugierte Kaninchen Polyklonal anti-C6orf150 Antikörper (ABIN7980137) detektiert spezifisch C6orf150 in WB, IHC und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für C6orf150 Antikörper (AA 352-504) (Biotin) (ABIN7980137)

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C6orf150 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-C6orf150 Antikörper (Biotin)

Bindungsspezifität: AA 352-504

Verwendungszweck: Anti-cGAS Antibody Biotin Conjugated

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human cGAS recombinant protein (Position: A352-F504).

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Andere Bezeichnung: cGAS

Hintergrund:

Background: cGAS (cyclic GMP-AMP synthase) is a cytosolic DNA sensor that serves to mount an immune response against the invasion of microbial pathogens such as viruses. cGAS normally resides as an inactive protein in the cell. Upon binding to DNA, cGAS undergoes a conformational change to an active state and produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP, which is subsequently detected by the cyclic-dinucleotide sensor STING, an ~40 kDa dimeric transmembrane protein at the endoplasmic reticulum (ER). cGAS not only is found in the cytosol but has a multifaceted cellular distribution that involves localization at the cell membrane and in the nucleus (PMID: 32424334). The calculated molecular weight of cGAS is 58 kDa. With post-translational modification, the MW of cGAS will be migrated to 70 kDa.

Gene Full Name: cyclic GMP-AMP synthase

Gen-ID: 214763

UniProt: Q8C6L5

Pathways: Activation of Innate immune Response