C19ORF80 Antikörper (AA 22-198) (APC)

Produktnummer ABIN7980066

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch C19ORF80 in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für C19ORF80 Antikörper (AA 22-198) (APC) (ABIN7980066)

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C19ORF80 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-C19ORF80 Antikörper (APC)

Bindungsspezifität: AA 22-198

Verwendungszweck: Anti-C19orf80/ANGPTL8 Antibody APC Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: Human C19orf80 shares 74% amino acid (aa) sequence identity with mouse C19orf80.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human C19orf80 recombinant protein (Position: A22-A198). Human C19orf80 shares 74% amino acid (aa) sequence identity with mouse C19orf80.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu C19ORF80

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Andere Bezeichnung: ANGPTL8

Hintergrund:

Background: ANGPTL8 (also known as lipasin, originally Betatrophin) is a protein that in humans is encoded by the C19orf80 gene. The gene for betatrophin lies on mouse chromosome 9 (gene symbol: Gm6484) and on human chromosome 19 (gene symbol: C19orf80). The encoded 22 kDa protein contains an N-terminal secretion signal and two coiled-coil domains and is a member of the angiopoietin-like (ANGPTL) protein family. However, in contrast to other ANGPTL proteins, betatrophin lacks the C-terminal fibrinogen-like domain, and therefore it is an atypical member of the ANGPTL family. It shares with Angptl4 and Angptl3 the ability to inhibit the enzyme Lipoprotein lipase (LPL), and its hepatic overexpression causes elevation of circulating Triglyceride levels in mice. In mice betatrophin is secreted by the liver. It was hoped that betatrophin or its homolog in humans may provide an effective treatment for type 2 diabetes and perhaps even type I diabetes.

Gene Full Name: angiopoietin like 8

Gen-ID: 55908

UniProt: Q6UXH0