Cathepsin K Antikörper (AA 115-329)

Produktnummer ABIN7975942

Der Kaninchen Polyklonal anti-Cathepsin K Antikörper wird verwendet zum Nachweis von Cathepsin K in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für Cathepsin K Antikörper (AA 115-329) (ABIN7975942)

Target: Cathepsin K (CTSK)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin K Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Produktdetails anti-Cathepsin K Antikörper

Bindungsspezifität: AA 115-329

Verwendungszweck: Anti-Cathepsin K/CTSK Antibody

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9%,88.8% amino acid (aa) sequence identity with mouse,rat Cathepsin K,respectively.

Produktmerkmale: Anti-Cathepsin K/CTSK Antibody. Tested in IHC, WB applications. This antibody reacts with Human.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human Western blot, 0.1-0.5 μg/mL, Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Cathepsin K

Target: Cathepsin K (CTSK)

Andere Bezeichnung: CTSK

Hintergrund:

Background: Cathepsin K, abbreviated?CTSK, is an?enzyme?that in humans is encoded by the?CTSK?gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal?cysteine protease?involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in?osteoclasts. Additionally, the enzyme's ability to catabolize?elastin,?collagen, and?gelatin?allow it to break down?bone?and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K?inhibitors, such as?odanacatib, show great potential in the treatment of?osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.

Gene Full Name: cathepsin K

Molekulargewicht: 45 kDa

Gen-ID: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades