Caspase 3 Antikörper (N-Term) (Cy3)

Produktnummer ABIN7975317

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Caspase 3 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für Caspase 3 Antikörper (N-Term) (Cy3) (ABIN7975317)

Target: Caspase 3 (CASP3)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 3 Antikörper ist konjugiert mit Cy3

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Caspase 3 Antikörper (Cy3)

Bindungsspezifität: N-Term

Verwendungszweck: Anti-Caspase-3(P17)/CASP3 Antibody Cy3 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: different from the related rat sequence by one amino acid.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse Caspase-3(P17), different from the related rat sequence by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Mouse Western blot, 0.1-0.5 μg/mL, Mouse, Rat

Kommentare:

Applications are recommended based on the unconjugated antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu Caspase 3

Target: Caspase 3 (CASP3)

Andere Bezeichnung: CASP3

Hintergrund:

Background: CASP3 (Caspase3 Apoptosis-Related Cysteine Protease), also known as YAMA, CPP32 or APOPAIN, is a caspase protein that interacts with caspase 8 and caspase 9. It is encoded by the CASP3 gene. The CASP3 protein is a member of the cysteine-aspartic acid protease (caspase) family. Tiso et al. (1996) used radiation hybrid mapping to localize the CPP32 gene to human chromosome 4q33-q35.1. Fernandes-Alnemri et al. (1994) found that overexpression of CPP32 in insect cells induced apoptosis. Coexpression of the 2 CPP32 subunits in insect cells also resulted in apoptosis. Tewari et al. (1995) showed that purified human ICE cleaved the Yama proenzyme into a proteolytically active form and that activated Yama cleaved PARP into the 85-kD apoptotic form.

Gene Full Name: caspase 3

Gen-ID: 12367

UniProt: P70677

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation