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DDB2 Antikörper (AA 201-300)

Der Kaninchen Polyklonal Anti-DDB2-Antikörper wurde für WB, ELISA, IF (cc), IF (p), IHC (fro) und IHC (p) validiert. Er ist geeignet, DDB2 in Proben von Maus und Ratte zu detektieren.
Produktnummer ABIN747803

Kurzübersicht für DDB2 Antikörper (AA 201-300) (ABIN747803)

Target

Alle DDB2 Antikörper anzeigen
DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Reaktivität

  • 44
  • 18
  • 12
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Maus, Ratte

Wirt

  • 44
  • 3
Kaninchen

Klonalität

  • 33
  • 14
Polyklonal

Konjugat

  • 29
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser DDB2 Antikörper ist unkonjugiert

Applikation

  • 29
  • 13
  • 10
  • 10
  • 8
  • 5
  • 5
  • 2
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300

    Spezifität

    This antibody may have a minor secondary cross-reactivity to TNFAIP3-interacting protein 2 due to a 63 % non-sequential sequence similarity in the immunogen region.

    Kreuzreaktivität

    Maus, Ratte

    Homologie

    Human,Cow,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human DDB2

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

    Andere Bezeichnung

    DDB2

    Hintergrund

    Synonyms: DDBB, UV-DDB2, DNA damage-binding protein 2, DDB p48 subunit, Damage-specific DNA-binding protein 2, UV-damaged DNA-binding protein 2, UV-DDB 2, DDB2

    Background: Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

    Gen-ID

    1643

    UniProt

    Q92466

    Pathways

    DNA Reparatur
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