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DDB2 Antikörper (AA 201-300)

This anti-DDB2 antibody (ABIN747803) is a Rabbit Polyclonal antibody detecting DDB2 in WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p). Suitable for Mouse, Rat.
Produktnummer ABIN747803

Quick Overview for DDB2 Antikörper (AA 201-300) (ABIN747803)

Target

Alle DDB2 Antikörper anzeigen
DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Reaktivität

  • 44
  • 18
  • 12
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Maus, Ratte

Wirt

  • 44
  • 3
Kaninchen

Klonalität

  • 33
  • 14
Polyklonal

Konjugat

  • 29
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser DDB2 Antikörper ist unkonjugiert

Applikation

  • 29
  • 13
  • 10
  • 10
  • 8
  • 5
  • 5
  • 2
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300

    Spezifität

    This antibody may have a minor secondary cross-reactivity to TNFAIP3-interacting protein 2 due to a 63 % non-sequential sequence similarity in the immunogen region.

    Kreuzreaktivität

    Maus, Ratte

    Homologie

    Human,Cow,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human DDB2

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

    Andere Bezeichnung

    DDB2

    Hintergrund

    Synonyms: DDBB, UV-DDB2, DNA damage-binding protein 2, DDB p48 subunit, Damage-specific DNA-binding protein 2, UV-damaged DNA-binding protein 2, UV-DDB 2, DDB2

    Background: Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

    Gen-ID

    1643

    UniProt

    Q92466

    Pathways

    DNA Reparatur
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