BARD1 Antikörper (AA 709-758) (Fluoro488)

Produktnummer ABIN7973149

Der Kaninchen Polyklonal anti-BARD1 Antikörper wird verwendet zum Nachweis von BARD1 in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für BARD1 Antikörper (AA 709-758) (Fluoro488) (ABIN7973149)

Target: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BARD1 Antikörper ist konjugiert mit Fluoro488

Applikation: Flow Cytometry (FACS)

Produktdetails anti-BARD1 Antikörper (Fluoro488)

Bindungsspezifität: AA 709-758

Verwendungszweck: Anti-BARD1 Antibody Fluoro488 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human BARD1 recombinant protein (Position: P709-A758).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu BARD1

Target: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Andere Bezeichnung: BARD1

Hintergrund:

Background: BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: BRCA1 associated RING domain 1

Gen-ID: 580

UniProt: Q99728

Pathways: DNA Reparatur