HNRNPC Antikörper

Produktnummer ABIN7938263

Der Kaninchen Polyklonal anti-HNRNPC Antikörper wird verwendet zum Nachweis von HNRNPC in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für HNRNPC Antikörper (ABIN7938263)

Target: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNRNPC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HNRNPC Antikörper

Verwendungszweck: HNRNPC antibody (pAb)

Aufreinigung: Protein A Chromatography

Immunogen: Peptide containing a sequence fragment corresponding to human heterogeneous nuclear ribonucleoprotein C.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.5 - 2 μg/mL For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.05 % Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu HNRNPC

Target: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Andere Bezeichnung: HNRNPC

Hintergrund:

Background_Plain: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C) is a member of the subfamily nuclear ribonucleoproteins (hnRNPs) involved in pre-mRNA processing, mRNA metabolism, and transport. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene (C1 and C2). HNRNPC is a critical alternative splicing regulator that complexes with heterogeneous nuclear RNA (hnRNA) and plays an essential role in RNA maturation, stabilization, translocation, and posttranscriptional modification. Cellular homeostasis, among other cellular processes, is regulated by RNA alternative splicing. Alternative splicing disfunction contributes to many disorders, including cancer. The up regulation of HNRNPC expression has been tied to cancer progression and is thought to function by regulating RNA splicing, RNA expression, RNA stability, mRNA translation, m6A RNA methylation, and dsRNA induced interferon response.

Aliases: Heterogeneous Nuclear Ribonucleoprotein C, hnRNP C, HNRPC

Molekulargewicht: 37 kDa

UniProt: P07910