CRTC2 Antikörper (pSer171) (Cy5.5)

Produktnummer ABIN745993

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CRTC2 in WB und FACS. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für CRTC2 Antikörper (pSer171) (Cy5.5) (ABIN745993)

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRTC2 Antikörper ist konjugiert mit Cy5.5

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-CRTC2 Antikörper (Cy5.5)

Bindungsspezifität: pSer171

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human CREB regulated transcription coactivator 2 around the phosphorylation site of Ser171

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Andere Bezeichnung: TORC2

Hintergrund:

Synonyms: TORC2, TORC-2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, Transducer of CREB protein 2, CRTC2

Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gen-ID: 200186

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis