NCOA3 Antikörper (pThr24) (Cy3)

Produktnummer ABIN745886

Der Kaninchen Polyklonal Anti-NCOA3-Antikörper wurde für IF (cc) und IF (p) validiert. Er ist geeignet, NCOA3 in Proben von Human zu detektieren.

Kurzübersicht für NCOA3 Antikörper (pThr24) (Cy3) (ABIN745886)

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOA3 Antikörper ist konjugiert mit Cy3

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-NCOA3 Antikörper (Cy3)

Bindungsspezifität: pThr24

Kreuzreaktivität: Human

Homologie: Pig,Horse,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human SRC-3 around the phosphorylation site of Thr24

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu NCOA3

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Andere Bezeichnung: Src-3

Hintergrund:

Synonyms: ACTR, AIB 1, AIB-1, AIB1, Amplied in breast cancer 1, Amplied in breast cancer 1 protein, bHLHe42, CAGH 16, CAGH16, CBP interacting protein, CBP-interacting protein, Class E basic helix-loop-helix protein 42, CTG 26, CTG26, KAT13B / AIB1, MGC141848, NCOA 3, NCOA 3, NCoA-3, Ncoa3, NCOA3_HUMAN, Nuclear receptor coactivator 3, pCIP, RAC 3, RAC-3, RAC3, Receptor associated coactivator 3, Receptor-associated coactivator 3, SRC 3, SRC-3, SRC3, Steroid receptor coactivator protein 3, Thyroid hormone receptor activator molecule 1, TNRC14, TNRC16, TRAM 1, TRAM-1, TRAM1.

Background: KAT13B/AIB1 interacts in a ligand-dependent fashion with the estrogen receptor to enhance estrogen-dependent transcriptional gene activation. The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits KAT3A / KAT3B as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

Gen-ID: 8202

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha