RCC1 Antikörper (pSer11)

Produktnummer ABIN745163

Produktdetails anti-RCC1 Antikörper

Target: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Bindungsspezifität: pSer11

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RCC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human RCC1 around the phosphorylation site of Ser11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RCC1

Target: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Andere Bezeichnung: RCC1 (RCC1 Produkte)

Synonyme: Chc1 antikoerper, zgc:65796 antikoerper, zgc:77114 antikoerper, wu:fj77f08 antikoerper, rcc1 antikoerper, chc1-a antikoerper, BJ1 antikoerper, CG10480 antikoerper, CG18640 (Bj1) antikoerper, Dmel\\CG10480 antikoerper, RCC1 antikoerper, RanGEF antikoerper, Rcc1 antikoerper, dRCC1 antikoerper, inxs antikoerper, sdt antikoerper, xrcc1 antikoerper, chc1-b antikoerper, MGC115703 antikoerper, MGC132085 antikoerper, CHC1 antikoerper, RCC1-I antikoerper, SNHG3-RCC1 antikoerper, 4931417M11Rik antikoerper, AI326872 antikoerper, regulator of chromosome condensation 1 antikoerper, regulator of chromosome condensation 1 L homeolog antikoerper, Regulator of chromosome condensation 1 antikoerper, N terminal fragment of RCC1; similar to S. cerevisiae SRM1 (YGL097W) guanine nucleotide exchange factor for Gsp1 GTPase involved in assembly of nuclear pore complex; frameshifted antikoerper, regulator of chromosome condensation 1 S homeolog antikoerper, rcc1 antikoerper, RCC1 antikoerper, rcc1.L antikoerper, Rcc1 antikoerper, rcc1.S antikoerper

Hintergrund:

Synonyms: Cell cycle regulatory protein, CHC 1, CHC1, Chromosome condensation 1, Chromosome condensation protein 1, Guanine nucleotide releasing protein, HERC2, Ran GEF, RanGEF, RCC 1, RCC1 I, Regulator of chromosome condensation 1, Regulator of chromosome condensation, SHEP1, RCC1_HUMAN.

Background: Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis. The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin , but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes.

Gen-ID: 1104

Pathways: Chromatin Binding, Protein targeting to Nucleus