TBXA2R Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885575

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TBXA2R in WB, FACS und LCI. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TBXA2R Antikörper (Extracellular, N-Term) (ABIN7885575)

Target: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBXA2R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-TBXA2R Antikörper

Bindungsspezifität: AA 13-27, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal antibody to Thromboxane A2 Receptor (extracellular).

Homologie: Mouse,rat - 12 out of 15 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RPTNITLEERRLIAS, corresponding to amino acid residues 13 - 27 of human TBXA2R 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237389)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu TBXA2R

Target: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Andere Bezeichnung: Prostanoid TP receptor

Hintergrund:

Synonyms: Prostanoid TP receptor, TXA2-R, TBXA2R

Description: Thromboxane A2 (TxA2) is a prostanoid that is synthesized from arachidonic acid and plays an important role in haemostasis, a process regulating platelet aggregation and vascular tone. Thromboxane A2 binds to the thromboxane A2 receptor (TBXA2R) to induce strong vasoconstriction in renal arteries.Thromboxane A2 receptor is a seven-transmembrane G-protein coupled receptor localized on the cell membrane and in intracellular compartments. TBXA2R is expressed in the central nervous system in several types of cells, such as microglia, oligodendrocytes and astrocytes. Imbalances in the levels of the receptor is widely implicated in several cardiovascular, pulmonary, renal and prostate pathologies1-3.Thromboxane A2 receptor mediates vasoconstriction and ischemia and its activation is implicated in atherosclerosis and inflammation. Activation of the receptor induces endothelial cell apoptosis by inhibiting Akt phosphorylation and also inhibits endothelial cell migration and angiogenesis by decreasing Akt and eNOS phosphorylation1-3.

Gen-ID: 6915

UniProt: P21731