TBXA2R Antikörper (3rd Intracellular Loop)

Produktnummer ABIN7885574

Der Kaninchen Polyklonal anti-TBXA2R Antikörper (ABIN7885574) detektiert spezifisch TBXA2R in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für TBXA2R Antikörper (3rd Intracellular Loop) (ABIN7885574)

Target: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBXA2R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: Carrier-free

Produktdetails anti-TBXA2R Antikörper

Bindungsspezifität: 3rd Intracellular Loop, AA 225-239

Verwendungszweck: A Rabbit Polyclonal Antibody to Thromboxane A2 Receptor

Homologie: Rat - 14,15 amino acid residues identical, human - 12, mouse - 13

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)HAREATQRPRD(S)EVE, corresponding to amino acid residues 225-239 of rat TBXA2R

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237385)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu TBXA2R

Target: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Andere Bezeichnung: Prostanoid TP receptor

Hintergrund:

Synonyms: Prostanoid TP receptor, TXA2-R, TBXA2R

Description: Thromboxane A2 (TxA2) is a prostanoid that is synthesized from arachidonic acid and plays an important role in haemostasis, a process regulating platelet aggregation and vascular tone. Thromboxane A2 binds to the thromboxane A2 receptor (TBXA2R) to induce strong vasoconstriction in renal arteries.Thromboxane A2 receptor is a seven-transmembrane G-protein coupled receptor localized on the cell membrane and in intracellular compartments. TBXA2R is expressed in the central nervous system in several types of cells, such as microglia, oligodendrocytes and astrocytes. Imbalances in the levels of the receptor is widely implicated in several cardiovascular, pulmonary, renal and prostate pathologies1-3.Thromboxane A2 receptor mediates vasoconstriction and ischemia and its activation is implicated in atherosclerosis and inflammation. Activation of the receptor induces endothelial cell apoptosis by inhibiting Akt phosphorylation and also inhibits endothelial cell migration and angiogenesis by decreasing Akt and eNOS phosphorylation1-3.

Gen-ID: 24816

UniProt: P34978