Tetraspanin 2 Antikörper (Extracellular, Loop 2)

Produktnummer ABIN7885571

Der Kaninchen Polyklonal anti-Tetraspanin 2 Antikörper (ABIN7885571) detektiert spezifisch Tetraspanin 2 in WB, FACS, IHC und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Tetraspanin 2 Antikörper (Extracellular, Loop 2) (ABIN7885571)

Target: Tetraspanin 2 (TSPAN2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tetraspanin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-Tetraspanin 2 Antikörper

Bindungsspezifität: AA 114-130, Extracellular, Loop 2

Verwendungszweck: A Rabbit Polyclonal antibody to Tetraspanin 2 (extracellular)

Homologie: Rat - identical,Human - 14 out of 17 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DVAIRHVQSMYEEAYSD, corresponding to amino acid residues 114 - 130 of mouse TSPAN2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Tetraspanin 2

Target: Tetraspanin 2 (TSPAN2)

Andere Bezeichnung: Tetraspan NET-3

Hintergrund:

Synonyms: Tetraspan NET-3, TSPAN2

Description: Tetraspanin 2 (TSPAN2) is a member of the Tetraspanin family of proteins, that comprises 33 members in humans. The family is characterized by the presence of four transmembrane domains, which give rise to the name "tetraspanin", as well as the presence two extracellular loops (EC1 and EC2), a small cytoplasmic loop, and short N- and C-terminal tails 1,2.Tetraspanins are able to interact with each other and also with numerous partner proteins such as integrins, growth factor receptors and ion channels, to create a dynamic network of interactions known as the tetraspanin-enriched microdomains (TEMs). Consequently, tetraspanins are regarded as molecular organizers and by forming complexes with these proteins, tetraspanins can modulate signal transduction pathways and cellular responses 2,3,4.Although TSPAN2 shares a relatively high homology with well-studied tetraspanins like CD9 (TSPAN29) or CD81 (TSPAN28), it has been less well-characterised up until now 3.Nevertheless, TSPAN2, like the related CD9 and CD81 proteins, has been described in relation to exosome formation, specifically regarding neuroinflammation and microglia activation 5, as well as oligodendrocyte differentiation into myelin-forming glia and in the progression of tumor metastasis by modulating cancer cell motility and invasion 3,5.

Gen-ID: 70747

UniProt: Q922J6