beta Synuclein Antikörper (C-Term, Intracellular)

Produktnummer ABIN7885564

Der Kaninchen Polyklonal anti-beta Synuclein Antikörper wird verwendet zum Nachweis von beta Synuclein in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für beta Synuclein Antikörper (C-Term, Intracellular) (ABIN7885564)

Target: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser beta Synuclein Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Produktdetails anti-beta Synuclein Antikörper

Bindungsspezifität: AA 86-99, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to β-Synuclein

Homologie: Mouse,human - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KEEFPTDLKPEEVA, corresponding to amino acid residues 86-99 of rat beta-synuclein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237362)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu beta Synuclein

Target: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Andere Bezeichnung: beta-Synuclein

Hintergrund:

Synonyms: β-Synuclein, Synuclein beta, PNP 14, SNCB

Description: β-Synuclein is a presynaptic protein that plays an important role in neuronal plasticity and synaptic vesicle regulation. The synuclein family includes three members: α, β and γ isoforms. The presynaptic proteins are detected in the neocortex, hippocampus, striatum, thalamus, and cerebellum regions1,2. β-Synuclein has been shown to act as a negative regulator of α-synuclein aggregation both in vivo and in vitro1,2. Structure wise, the protein contains a highly conserved N-terminal domain which includes a repetitive amino acid motif, and a more divergent and highly acidic stretch at the C-terminal domain2,3.Studies have shown overexpressed mRNA levels of β-synuclein in Parkinson's disease suggesting that the protein has a valuable role in maintaining homeostasis in the disease pathology. In addition, studies have shown the action of β-synuclein as a neurodegeneration-inducing factor that can cause cell loss when expressed in rat brains1,2.β-Synuclein is also implicated with dementia involving Lewy bodies. To date, two mutations in the protein, V70M and P123H, have been identified in the sporadic and familial disease3.

Gen-ID: 113893

UniProt: Q63754