Stim2 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7885544

Der Kaninchen Polyklonal anti-Stim2 Antikörper (ABIN7885544) detektiert spezifisch Stim2 in WB, IHC, IF und IC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Stim2 Antikörper (C-Term, Intracellular) (ABIN7885544)

Target: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Stim2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Güteklasse: Carrier-free, KO Validated

Produktdetails anti-Stim2 Antikörper

Bindungsspezifität: AA 583-597, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to STIM2

Homologie: Rat,mouse,bovine - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: SAEKQWEVPDTASEC, corresponding to amino acid residues 583-597 of human STIM2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:100

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237296)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Stim2

Target: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Andere Bezeichnung: Stromal interaction molecule 2

Hintergrund:

Synonyms: Stromal interaction molecule 2

Description: Cytosolic Ca2+ has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation.1,2 The mechanism controlling the influx of intracellular Ca2+ either by calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores has lately become the focus of intense research.Recently, several key players of the store-operated complex have been identified: the Orai family consists of three members: Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2.3 Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum (ER) Ca2+ sensor.3,4While STIM1 appears to be localized intracellularly at the ER membrane and at a much lower extent on the cell surface of several cell types, STIM2 appears to be localized solely at the ER membrane.5 The function of STIM2 still remains elusive and several models have been suggested.6-8

Gen-ID: 57620

UniProt: Q9P246

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling