Neuregulin 3 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885165

Der Kaninchen Polyklonal anti-Neuregulin 3 Antikörper wird verwendet zum Nachweis von Neuregulin 3 in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für Neuregulin 3 Antikörper (Extracellular, N-Term) (ABIN7885165)

Target: Neuregulin 3 (NRG3)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Produktdetails anti-Neuregulin 3 Antikörper

Bindungsspezifität: AA 167-180, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Neuregulin-3

Homologie: Human,rat - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RFPGHRVPIRASPR, corresponding to amino acid residues 167-180 of mouse Neuregulin-3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236034)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Neuregulin 3

Target: Neuregulin 3 (NRG3)

Andere Bezeichnung: Neuregulin-3

Hintergrund:

Synonyms: Neuregulin-3, HRG3

Description: Neuregulins (NRGs) are single-pass membrane proteins belonging to a multi member family of epidermal growth factor (EGF)-like signaling molecules involved in cell-cell communication. This family includes four human neuregulin paralogs NRG1-NRG4 with multiple isoforms through alternative splicing1.Neuregulin 3 (NRG3) plays a key role in the embryonic cerebral cortex development by regulating the migration and patterning of neural progenitor cells. It specifically binds to the ErbB4 receptor tyrosine kinase in the developing mammalian forebrain2,3.Neuregulin 3 is almost exclusively expressed in the nervous system with highest expression in the anterior cingulate and frontal cortex3,4.Mutations in the neuregulin 3 gene are linked to different mental disorders accompanied with cognitive and behavioral abnormalities such as developmental delay, cognitive impairment, and psychiatric illness2,3. Single nucleotide polymorphisms are associated with delusions in patients with schizophrenia and linked to the disease itself. Knockout mice display novelty-induced hyperactivity and are deficient fear conditioning4.

Gen-ID: 18183

UniProt: O35181

Pathways: RTK Signalweg