HRH2 Antikörper (2nd Extracellular Loop)

Produktnummer ABIN7885078

Der Kaninchen Polyklonal anti-HRH2 Antikörper wird verwendet zum Nachweis von HRH2 in Proben von Ratte und Maus. Er wurde validiert für WB, IF, IHC, FACS, IC und LCI.

Kurzübersicht für HRH2 Antikörper (2nd Extracellular Loop) (ABIN7885078)

Target: HRH2 (Histamine Receptor H2 (HRH2))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HRH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunochromatography (IC), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-HRH2 Antikörper

Bindungsspezifität: 2nd Extracellular Loop

Verwendungszweck: A Rabbit Polyclonal Antibody to Histamine H2 Receptor

Homologie: Mouse - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: RNGTRGGNDTFKC, corresponding to amino acids 161-173 of rat HRH2 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 1:20

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235754)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu HRH2

Target: HRH2 (Histamine Receptor H2 (HRH2))

Andere Bezeichnung: H2R

Hintergrund:

Synonyms: H2R, HH2R, Gastric receptor I, Gastric receptor 1

Description: Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1,2The biological effects of histamine are mediated through four receptors (H1-H4 receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.H2 receptors couple to adenylate cyclase via Gs, leading to the formation of cAMP and the activation of protein kinase A (PKA).1,2 H2 receptors are expressed in several tissues including the brain, gastrointestinal tract and heart.The most studied physiological role of the H2 receptor is its involvement in the regulation of gastric acid secretion.3 Specific H2 receptor antagonists are currently used for the treatment of acid-related gastrointestinal conditions such as peptic ulcer, gastroesophageal reflux disease and dyspepsia.Involvement of H2 receptors in chronic heart failure and immune regulation has also been suggested.

Gen-ID: 25461

UniProt: P25102