Glucagon Receptor Antikörper (1st Extracellular Loop)

Produktnummer ABIN7885043

Der Kaninchen Polyklonal anti-Glucagon Receptor Antikörper (ABIN7885043) detektiert spezifisch Glucagon Receptor in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Glucagon Receptor Antikörper (1st Extracellular Loop) (ABIN7885043)

Target: Glucagon Receptor (GCGR)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glucagon Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: Carrier-free

Produktdetails anti-Glucagon Receptor Antikörper

Bindungsspezifität: 1st Extracellular Loop, AA 200-212

Verwendungszweck: A Rabbit Polyclonal Antibody to Glucagon Receptor

Homologie: Mouse - identical, human - 12,13 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KTRYSQKIGDDLS, corresponding to amino acid residues 200-212 of rat GCGR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235603)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Glucagon Receptor

Target: Glucagon Receptor (GCGR)

Andere Bezeichnung: GCGR

Hintergrund:

Synonyms: GCGR, GLR

Description: The glucagon receptor (GCGR) is one of the 15 members of the secretin-like (class B) family of G-protein-coupled receptors (GPCRs) in humans. Glucagon is a highly conserved 29 amino acid protein processed from proglucagon by PC2 in pancreatic α-cells. The principal actions of glucagon involve regulation of metabolic pathways involved in glucose homeostasis1. Glucagon binding to the GCGR activates adenylyl cyclase through heterotrimeric Gs G proteins, leading to an increase in intracellular cAMP levels and subsequent activation of PKA signaling2. The glucagon receptor is a 485-amino acid protein with a central core consisting of seven membrane-spanning domains, an extracellular N-terminus and a cytoplasmic C-terminal tail2.Glucagon receptors are widely expressed in multiple tissues including the liver, brain, pancreas, heart, kidney, and smooth muscle cell in the gastrointestinal tract and peripheral vasculature1.Abnormal glucagon signaling is associated with hyperglycemia in patients with type 2 diabetes3. Mice with homozygous null mutation of GCGR exhibit chronic hypoglycemia, extreme hyperglucagonemia, and α cell hyperplasia4. GCGR is a potential drug target for type 2 diabetes5.

Gen-ID: 24953

UniProt: P30082

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process