Ephrin A5 Antikörper (Extracellular)

Produktnummer ABIN7884944

Der Kaninchen Polyklonal anti-Ephrin A5 Antikörper (ABIN7884944) detektiert spezifisch Ephrin A5 in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für Ephrin A5 Antikörper (Extracellular) (ABIN7884944)

Target: Ephrin A5 (EFNA5)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ephrin A5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: Carrier-free

Produktdetails anti-Ephrin A5 Antikörper

Bindungsspezifität: AA 172-186, Extracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Ephrin A5

Homologie: Mouse,rat - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DRVFDVNDKVENSLE, corresponding to amino acid residues 172-186 of human Ephrin-A5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235310)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Ephrin A5

Target: Ephrin A5 (EFNA5)

Andere Bezeichnung: EPH-related receptor tyrosine kinase ligand 7

Hintergrund:

Synonyms: EPH-related receptor tyrosine kinase ligand 7, LERK7, AL-1, EFNA5

Description: The Eph family of tyrosine kinase receptor signaling pathway is important for a variety of physiological processes during development including cell morphology, proliferation, migration and axonal guidance, dendritic spine formation and neural plasticity. Eph receptors mediate forward signaling in one cell while ephrin ligands transmit reverse signaling in an adjacent cell1-3.Eph receptors consist of two large subfamilies: EphA and EphB that bind to either glycophosphatidylinositol (GPI)-anchored ephrin-A ligands or transmembrane ephrin-B ligands respectively. Ephrin ligands are divided into ephrin-A (1 to 5) and ephrin-B (1 to 3)1,2.Ephrin-A5 is predominantly expressed in the quiescent anterior lens epithelial cells and is highly expressed in different layers of the cortex2,3.Studies show that mutations in ephrin-A5 are linked to congenital and age-related cataracts in humans and mice. Loss of ephrin-A5 causes abnormal localization of E-cadherin and β-catenin in anterior epithelial cells and epithelial-mesenchymal-transition2.

Gen-ID: 1946

UniProt: P52803

Pathways: RTK Signalweg