DPP10 Antikörper (C-Term, Extracellular)

Produktnummer ABIN7884912

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DPP10 in WB, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für DPP10 Antikörper (C-Term, Extracellular) (ABIN7884912)

Target: DPP10 (Dipeptidylpeptidase 10 (DPP10))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DPP10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: Carrier-free

Produktdetails anti-DPP10 Antikörper

Bindungsspezifität: AA 356-370, C-Term, Extracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Dipeptidyl Peptidase 10

Homologie: 15 amino acid residues identical,Mouse - 14, human - 12

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CSRKYEMTSDTWISK, corresponding to amino acid residues 356-370 of rat DPP10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:1000

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235212)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu DPP10

Target: DPP10 (Dipeptidylpeptidase 10 (DPP10))

Andere Bezeichnung: Inactive dipeptidyl peptidase 10

Hintergrund:

Synonyms: Inactive dipeptidyl peptidase 10, Dipeptidyl peptidase X, DPP X, DPPY, DPL2, DPRP3

Description: Dipeptidyl peptidase 10 (DPP10, DPPY) is a member of the prolyl oligopeptidase family (shares a 30 % sequence identity with DPP4) and belongs to the S9B serine protease subfamily. DPP10 is a homologous glycosylated, single-pass type II transmembrane protein that lacks the crucial serine residue of the catalytic triad. Unlike other KV4 subunits such as DPP6, DPP10 has a restricted expression pattern including the brain, adrenal gland and pancreas. The presence of DPP10 in endocrine cells suggests that the protein may also have an additional function related to the regulation of hormone secretion. DPP10 accelerates the activation and inactivation of KV4.3 channel gating with distinct biophysical properties.DPP10 associates with the α-subunits of the KV4 subfamily to form a ternary complex of approximately 750 kDa1. In addition, DPP10 forms complexes with other auxiliary subunits of the KV4 channels. In dorsal root ganglion DPP10 is co-localized with K+ channel-interacting proteins 1 and 2 (KChIPs) in the somatic surface and cytoplasm of KV4.3 nociceptors. Recently it has been hypothesized that KV4/KChIP/DPPL ternary complexes exist in subthreshold A-type K+ currents (Isas) expressing nociceptors and pain-modulating spinal interneurons2.DPP10 has been implicated in various pathologies. Aggregation of the protein is associated with neurodegenerative conditions such as Alzheimer's, diffuse Lewy body disease and fronto-temporal dementia3.

Gen-ID: 363972

UniProt: Q6Q629