CCKBR Antikörper (Extracellular, N-Term)

Produktnummer ABIN7884878

Der Kaninchen Polyklonal anti-CCKBR Antikörper (ABIN7884878) detektiert spezifisch CCKBR in WB, IHC, FACS und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für CCKBR Antikörper (Extracellular, N-Term) (ABIN7884878)

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCKBR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-CCKBR Antikörper

Bindungsspezifität: AA 39-53, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to the Cholecystokinin B Receptor

Homologie: human - 13,Rat - 14,15 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CETPRIRGTGTRELE, corresponding to amino acid residues 39-53 of mouse Gastrin/cholecystokinin type B receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100-1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235114)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu CCKBR

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Andere Bezeichnung: Cholecystokinin B receptor

Hintergrund:

Synonyms: Cholecystokinin B receptor, Gastrin receptor, CCK2R, GASR

Description: Cholecystokinin B receptor (CCKBR), also known as the Gastrin receptor and CCKR2, belongs to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily, and is one of the two receptors that mediates the effects of the cholecystokinin (CCK) and gastrin peptides1,2.CCK and gastrin are related linear peptides that occur in different forms but share the last five C-terminal amino acid residues. CCK regulates several nutritional-related activities such as stimulation of pancreatic exocrine secretion or the regulation of intestinal transit, while gastrin's main function is the stimulation of gastric acid secretion1,2.Both CCKBR and the other CCK receptor (CCKAR or CCK1R) are coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), and intracellular Ca2+mobilization.CCKBR was originally identified in the brain (and hence its name, type B for Brain) where it is widely distributed, notably in the cerebral cortex and striatum. In the periphery, CCKBR is most notably expressed in acid secreting cells in the mucosa of the stomach. The tissue distribution of CCKBR corresponds to the proposed roles of the receptor which include anxiety, pain perception, gastric acid secretion, and growth and differentiation of the gastric mucosa1,2.

Gen-ID: 12426

UniProt: P56481

Pathways: Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour