CADM1 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7884855

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CADM1 in WB, IHC, FACS und LCI. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für CADM1 Antikörper (Extracellular, N-Term) (ABIN7884855)

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CADM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-CADM1 Antikörper

Bindungsspezifität: AA 148-163, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal antibody to CADM1/SynCAM (extracellular)

Homologie: Rat,human - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RNLMIDIQKDTAVEGE, corresponding to amino acid residues 148 - 163 of mouse CADM1 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:500

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu CADM1

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Andere Bezeichnung: Cell Adhesion Molecule 1

Hintergrund:

Synonyms: Cell Adhesion Molecule 1, Synaptic Cell Adhesion Molecule, Nectin-Like 2, NECL-2, Immunoglobulin Superfamily Member 4, IgSF4

Description: SynCAMs are a family of 4 proteins (SynCAM1-4) belonging to the immunoglobulin superfamily of cell adhesion molecules (IgCAMs) and are encoded by the cell adhesion molecule 1-4 (CADM1-4) genes1-3.Evolutionarily, SynCAMs are a fairly recent gene lineage since they are only found in vertebrates1, in contrast to much older synaptogenic adhesion molecules such as neuroligins, which appeared concurrently with the evolution of the first synapses around one billion years ago, or compared to even older protosynaptic adhesion molecules including neurexins and NCAM4.CADM1 (also known as SynCAM1), by far the most studied family member, was identified nearly simultaneously in multiple tissue types and therefore is known by a number of different protein names including immunoglobulin subfamily member 4 (IGSF4)5, spermatogenic immunoglobulin superfamily (SgIGSF)6, and RA1757.CADM1 was also initially discovered as a tumor suppressor gene and termed tumor suppressor in non-small cell lung cancer (TSLC1)8. In fact, CADM1 is downregulated in several tumors including lung, ovarian, hepatocellular carcinoma and glioblastoma, and has been proposed as both a biomarker of malignancy and a therapeutic target9.In addition, CADM1 knockout mice have impaired ultrasonic vocalization, a method for mother-offspring communication, which supports a role for CADM1 in autism spectrum disorders (ASD)10.

Gen-ID: 54725

UniProt: Q8R5M8

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation