CADM1 Antikörper (N-Term)

Produktnummer ABIN654660

Produktdetails anti-CADM1 Antikörper

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Bindungsspezifität: AA 66-94, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CADM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CADM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human CADM1.

Klon: RB22685

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu CADM1

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Andere Bezeichnung: CADM1 (CADM1 Produkte)

Synonyme: BL2 antikoerper, IGSF4 antikoerper, IGSF4A antikoerper, NECL2 antikoerper, Necl-2 antikoerper, RA175 antikoerper, ST17 antikoerper, SYNCAM antikoerper, TSLC1 antikoerper, sTSLC-1 antikoerper, sgIGSF antikoerper, synCAM1 antikoerper, bl2 antikoerper, igsf4 antikoerper, igsf4a antikoerper, necl-2 antikoerper, necl2 antikoerper, ra175 antikoerper, sgigsf antikoerper, st17 antikoerper, stslc-1 antikoerper, syncam antikoerper, syncam1 antikoerper, tslc1 antikoerper, xnecl2 antikoerper, 2900073G06Rik antikoerper, 3100001I08Rik antikoerper, AI987920 antikoerper, Bl2 antikoerper, Igsf4 antikoerper, Igsf4a antikoerper, Necl2 antikoerper, RA175A antikoerper, RA175B antikoerper, RA175C antikoerper, RA175N antikoerper, SgIGSF antikoerper, SynCam antikoerper, Tslc1 antikoerper, SynCAM1 antikoerper, cell adhesion molecule 1 antikoerper, cell adhesion molecule 1 L homeolog antikoerper, CADM1 antikoerper, cadm1.L antikoerper, Cadm1 antikoerper

Hintergrund: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Molekulargewicht: 48509

Gen-ID: 23705

NCBI Accession: NP_001091987, NP_055148

UniProt: Q9BY67

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation