Vitamin D Receptor Antikörper

Produktnummer ABIN7882684

Der Kaninchen Monoklonal anti-Vitamin D Receptor Antikörper wird verwendet zum Nachweis von Vitamin D Receptor in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für Vitamin D Receptor Antikörper (ABIN7882684)

Target: Vitamin D Receptor (VDR)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Vitamin D Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: AAGE-22

Produktdetails anti-Vitamin D Receptor Antikörper

Verwendungszweck: Vitamin D Receptor Antibody / VDR

Aufreinigung: Affinity purified

Immunogen: A synthetic peptide specific to human Vitamin D Receptor / VDR was used as the immunogen for the Vitamin D Receptor antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Vitamin D Receptor antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the Vitamin D Receptor antibody at -20oC.

Details zu Vitamin D Receptor

Target: Vitamin D Receptor (VDR)

Andere Bezeichnung: Vitamin D Receptor

Substanzklasse: Chemical

Hintergrund: The VDR gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [RefSeq]

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway