Rekombinanter UFD1L Antikörper

Produktnummer ABIN7882625

Der Kaninchen Monoklonal anti-UFD1L Antikörper (Klon 29U95) (ABIN7882625) detektiert spezifisch UFD1L in WB, IF, ICC und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter UFD1L Antikörper (ABIN7882625)

Target: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser UFD1L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 29U95

Produktdetails anti-UFD1L Antikörper

Verwendungszweck: UFD1L Antibody / Ubiquitin Fusion Degradation 1 Like

Aufreinigung: Affinity chromatography

Immunogen: A synthesized peptide derived from human UFD1L was used as the immunogen for the UFD1L antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the UFD1L antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the UFD1L antibody at -20oC.

Details zu UFD1L

Target: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Andere Bezeichnung: UFD1L

Hintergrund: UFD1L antibody detects Ubiquitin fusion degradation protein 1 like, encoded by the UFD1L gene. Ubiquitin fusion degradation protein 1 like forms a complex with NPL4 and the ATPase p97/VCP to regulate extraction of ubiquitinated substrates from membranes and protein complexes. This activity is essential for protein quality control, endoplasmic reticulum associated degradation, and mitotic progression. UFD1L antibody provides researchers with an important tool for studying ubiquitin signaling, proteostasis, and cell cycle regulation.

The UFD1L-NPL4-p97 complex functions as a segregase, using ATP hydrolysis to unfold and extract ubiquitinated proteins for degradation by the proteasome. Research using UFD1L antibody has demonstrated that this complex acts in multiple pathways, including clearance of misfolded proteins from the endoplasmic reticulum, disassembly of protein aggregates, and regulation of spindle assembly during mitosis. Its versatile roles make UFD1L a central hub in protein quality control networks.

Mutations and deletions involving UFD1L are associated with genetic disorders. Studies with UFD1L antibody have shown that haploinsufficiency contributes to DiGeorge syndrome, a developmental disorder characterized by congenital heart defects, immune dysfunction, and craniofacial anomalies. Because UFD1L is located in the 22q11 region, deletions that remove this gene disrupt proteostasis during development, contributing to disease phenotypes.

In cancer biology, UFD1L has been implicated in regulating cell proliferation and survival. Research using UFD1L antibody has revealed that overexpression enhances proteasomal degradation of regulatory proteins, supporting uncontrolled growth. Conversely, loss of function can cause accumulation of toxic aggregates, impairing viability. These dual roles highlight its importance in maintaining balanced proteostasis across different contexts.

UFD1L antibody is widely used in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting identifies endogenous levels, immunohistochemistry localizes expression in developmental tissues, and immunoprecipitation demonstrates interactions with p97/VCP and NPL4. These applications make UFD1L antibody essential in both developmental and disease research.

By supplying validated UFD1L antibody reagents, NSJ Bioreagents supports studies into proteostasis, ER associated degradation, and developmental biology. Detection of Ubiquitin fusion degradation protein 1 like provides insight into how protein quality control influences health and disease.

UniProt: Q92890