Rekombinanter Thyroglobulin Antikörper

Produktnummer ABIN7882475

Der Maus Monoklonal anti-Thyroglobulin Antikörper (Klon rTGB-4744) (ABIN7882475) detektiert spezifisch Thyroglobulin in FACS und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Thyroglobulin Antikörper (ABIN7882475)

Target: Thyroglobulin (TG)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Thyroglobulin Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RTGB-4744

Produktdetails anti-Thyroglobulin Antikörper

Verwendungszweck: Recombinant Thyroglobulin Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: Human thyroid follicular cells were used as the immunogen for the recombinant Thyroglobulin antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant Thyroglobulin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant Thyroglobulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Thyroglobulin

Target: Thyroglobulin (TG)

Andere Bezeichnung: Thyroglobulin

Hintergrund: MAb rTGB/4744 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by mAb < a href=../search_result.php?search_txt=6e1>6E1. Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

UniProt: P01266

Pathways: Thyroid Hormone Synthesis