RAD21 Antikörper
Kurzübersicht für RAD21 Antikörper (ABIN7882129)
Target
Alle RAD21 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Rad21 Antibody
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Aufreinigung
- Affinity purified
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Immunogen
- A synthetic peptide specific to human Rad21 was used as the immunogen for the Rad21 antibody.
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Isotyp
- IgG
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Applikationshinweise
- Optimal dilution of the Rad21 antibody should be determined by the researcher.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store the Rad21 antibody at -20oC.
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- RAD21 (RAD21 Homolog (RAD21))
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Andere Bezeichnung
- Rad21
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Hintergrund
- Double-strand-break repair protein rad21 homolog' is a cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. [UniProt]
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UniProt
- O60216
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Pathways
- Positive Regulation of Endopeptidase Activity
Target
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