Rekombinanter PAI1 Antikörper

Produktnummer ABIN7881956

Der Kaninchen Monoklonal anti-PAI1 Antikörper (Klon ABHG-19) (ABIN7881956) detektiert spezifisch PAI1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter PAI1 Antikörper (ABIN7881956)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PAI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: ABHG-19

Produktdetails anti-PAI1 Antikörper

Verwendungszweck: PAI-1 Antibody / Plasminogen activator inhibitor 1 / SERPINE1

Aufreinigung: Affinity purified

Immunogen: A synthetic peptide specific to human PAI1 / SERPINE1 was used as the immunogen for the PAI-1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PAI-1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the PAI-1 antibody at -20oC.

Details zu PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Andere Bezeichnung: PAI-1

Hintergrund: PAI-1 antibody, also known as Plasminogen activator inhibitor 1 antibody, recognizes a secreted serine protease inhibitor encoded by the SERPINE1 gene and commonly referred to as Serpin E1 and endothelial plasminogen activator inhibitor. Plasminogen activator inhibitor 1 is a member of the serpin superfamily and is localized predominantly to the extracellular space and circulating plasma, where it tightly regulates fibrinolysis. It is highly expressed in endothelial cells, adipocytes, hepatocytes, platelets, smooth muscle cells, and various tumor cell types, with expression levels increasing in response to inflammatory cytokines, hypoxia, metabolic stress, and tissue injury.

Plasminogen activator inhibitor 1 functions as the primary physiological inhibitor of tissue-type plasminogen activator and urokinase-type plasminogen activator, thereby limiting plasmin generation and stabilizing fibrin clots. Through this antifibrinolytic activity, it plays a critical role in thrombosis, wound healing, and extracellular matrix remodeling. Beyond hemostasis, PAI-1 is actively involved in angiogenesis, cell adhesion, migration, and tumor invasion through interactions with vitronectin and the urokinase receptor complex. PAI-1 antibody is frequently used in studies investigating coagulation biology, vascular pathology, and tumor microenvironment signaling.

Structurally, Plasminogen activator inhibitor 1 contains the conserved reactive center loop characteristic of serpin family members, allowing it to form stable inhibitory complexes with target proteases. The protein exists in active, latent, and cleaved conformations, each with distinct functional implications. Binding to vitronectin stabilizes the active conformation and prolongs its half-life in circulation. Within tissues, PAI-1 is detected in the pericellular matrix and extracellular compartment, often co-localizing with integrins and components of the plasminogen activation system during dynamic remodeling processes.

Dysregulation of SERPINE1 expression is strongly associated with human disease. Elevated PAI-1 levels are linked to deep vein thrombosis, myocardial infarction, atherosclerosis, and other cardiovascular disorders characterized by impaired fibrinolysis. Increased expression is also observed in obesity and type 2 diabetes, contributing to metabolic and vascular complications. In oncology, high SERPINE1 expression correlates with poor prognosis in several malignancies, including breast, lung, and colorectal cancers, where it supports tumor cell survival, invasion, and resistance to apoptosis.

PAI-1 antibody supports research into TGF-beta signaling, hypoxia-inducible factor pathways, and inflammatory cytokine networks that regulate SERPINE1 transcription. Developmentally, PAI-1 expression increases during tissue repair and inflammatory responses, reflecting its role in controlled matrix turnover and immune regulation. Clone ABHG-19 recognizes Plasminogen activator inhibitor 1 and is suitable for detecting PAI-1 expression in relevant research applications.

UniProt: P05121

Pathways: p53 Signalweg, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagie, Smooth Muscle Cell Migration