Patched 2 Antikörper

Produktnummer ABIN7881908

Der Kaninchen Polyklonal anti-Patched 2 Antikörper (ABIN7881908) detektiert spezifisch Patched 2 in WB, IF und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Patched 2 Antikörper (ABIN7881908)

Target: Patched 2 (PTCH2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Patched 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Patched 2 Antikörper

Verwendungszweck: Patched 2 Antibody / PTCH2

Sequenz: FDYAHSQRAL FDLHQR

Aufreinigung: Affinity purified

Immunogen: Amino acids FDYAHSQRALFDLHQR from the human protein were used as the immunogen for the Patched 2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Patched 2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Patched 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Patched 2

Target: Patched 2 (PTCH2)

Andere Bezeichnung: Patched 2

Hintergrund: PTCH2 (patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for Ptch2 in adult epidermal homeostasis via Shh signaling.

UniProt: Q9Y6C5

Pathways: Hedgehog Signalweg