MBP Antikörper

Produktnummer ABIN7881703

Der Ratte Monoklonal anti-MBP Antikörper wird verwendet zum Nachweis von MBP in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für MBP Antikörper (ABIN7881703)

Target: MBP (Myelin Basic Protein (MBP))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser MBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: MBP-4274

Produktdetails anti-MBP Antikörper

Verwendungszweck: Myelin Basic Protein Antibody (azide and preservative free)

Sequenz: GILDSIGRFF GGDRG

Aufreinigung: Protein G affinity chromatography

Immunogen: Amino acids GILDSIGRFFGGDRG from the human protein were used as the immunogen for the Myelin Basic Protein antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Myelin Basic Protein antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Myelin Basic Protein antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu MBP

Target: MBP (Myelin Basic Protein (MBP))

Andere Bezeichnung: Myelin Basic Protein

Hintergrund: Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30 % of the total protein and about 10 % of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. MBP/4274 recognizes an epitope in the 36-50 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP.

UniProt: P02686