Keratin 7/17 Antikörper

Produktnummer ABIN7881419

Der Maus Monoklonal anti-Keratin 7/17 Antikörper (Klon C-46) (ABIN7881419) detektiert spezifisch Keratin 7/17 in WB, IHC (p) und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Keratin 7/17 Antikörper (ABIN7881419)

Target: Keratin 7/17 (KRT7/17)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Keratin 7/17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Klon: C-46

Produktdetails anti-Keratin 7/17 Antikörper

Verwendungszweck: Cytokeratin 7/17 Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: A cytoskeletal preparation from human HeLa cells was used as the immunogen for this Cytokeratin 7/17 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Cytokeratin 7/17 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Cytokeratin 7/17 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Keratin 7/17

Target: Keratin 7/17 (KRT7/17)

Andere Bezeichnung: Cytokeratin 7/17

Hintergrund: It recognizes intermediate filament proteins (IFP's) of 55 kDa and 46 kDa, which are identified as Cytokeratin 7 and Cytokeratin 17 respectively. On formalin-fixed, paraffin embedded sections, C-46 reacts with Keratin 7 only. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 7 is a basic cytokeratin, which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Cytokeratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of colon, prostate, or gastrointestinal tract. Cytokeratin 17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. Cytokeratin 17 antibody marks basal cell differentiation.

UniProt: P08729