Rekombinanter Iba1 Antikörper

Produktnummer ABIN7881326

Der Kaninchen Monoklonal anti-Iba1 Antikörper (Klon 31A74) (ABIN7881326) detektiert spezifisch Iba1 in WB, IHC, ICC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für Rekombinanter Iba1 Antikörper (ABIN7881326)

Target: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Iba1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon: 31A74

Produktdetails anti-Iba1 Antikörper

Verwendungszweck: AIF1 Antibody / IBA1

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Iba1 was used as the immunogen for the AIF1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the AIF1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the AIF1 antibody at -20oC.

Details zu Iba1

Target: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Andere Bezeichnung: AIF1

Hintergrund: IBA1 antibody detects allograft inflammatory factor 1 (AIF1), a calcium-binding protein expressed in microglia and macrophages. IBA1 participates in actin cytoskeleton remodeling, enabling immune cells to migrate and phagocytose effectively. In the central nervous system, it serves as a widely used microglial marker, allowing researchers to monitor immune responses within brain tissue. Its expression increases during neuroinflammation, making it valuable for studying disease-related activation states.

Applications of IBA1 antibody include research on Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury. Microglial activation visualized through IBA1 staining helps define the extent and nature of neuroimmune involvement in these conditions. Beyond neuroscience, AIF1 is also expressed in peripheral macrophages, where it regulates inflammatory pathways and vascular remodeling, linking it to atherosclerosis and transplant rejection models.

Antibodies against IBA1 are validated for immunohistochemistry, immunofluorescence, and western blot. These tools allow precise localization of microglia and provide insights into how immune cells interact with neurons and glia in health and disease. Clone-based products ensure high specificity with minimal background staining.

NSJ Bioreagents provides this IBA1 antibody for research applications in neuroscience, inflammation, and immunology. Alternate names include allograft inflammatory factor 1 antibody, ionized calcium-binding adapter molecule 1 antibody, and microglial marker antibody.

UniProt: P55008

Pathways: Smooth Muscle Cell Migration