IL2RG Antikörper

Produktnummer ABIN7881295

Der Kaninchen Polyklonal anti-IL2RG Antikörper wird verwendet zum Nachweis von IL2RG in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IF.

Kurzübersicht für IL2RG Antikörper (ABIN7881295)

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL2RG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-IL2RG Antikörper

Verwendungszweck: IL2RG Antibody / IL2 Receptor gamma

Sequenz: QLQKKEIHLY QTFVVQLQD

Aufreinigung: Affinity purified

Immunogen: Amino acids QLQKKEIHLYQTFVVQLQD from the human protein were used as the immunogen for the IL2RG antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IL2RG antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the IL2RG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu IL2RG

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Andere Bezeichnung: IL2RG

Hintergrund: IL2RG (INTERLEUKIN 2 RECEPTOR, GAMMA),also known as Common gamma chain or CD132, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors:IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte(white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, The IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL2 receptor. Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and direct programs of cellular differentiation. The sharing of the gamma subunit by several receptors explains why humans and mice that lack IL2 entirely show milder symptoms than those with IL2RG deficiency.

UniProt: P31785

Pathways: JAK-STAT Signalweg, Growth Factor Binding