Rekombinanter IL18BP Antikörper

Produktnummer ABIN7881287

Der Kaninchen Monoklonal anti-IL18BP Antikörper (Klon 31I00) (ABIN7881287) detektiert spezifisch IL18BP in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für Rekombinanter IL18BP Antikörper (ABIN7881287)

Target: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser IL18BP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: 31I00

Produktdetails anti-IL18BP Antikörper

Verwendungszweck: IL18BP Antibody / IL18 binding protein

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human IL18 binding protein was used as the immunogen for the IL18BP antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IL18BP antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the IL18BP antibody at -20oC.

Details zu IL18BP

Target: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Andere Bezeichnung: IL18BP

Hintergrund: IL18BP antibody detects interleukin 18 binding protein, encoded by the IL18BP gene. This secreted glycoprotein functions as a natural inhibitor of interleukin 18, a proinflammatory cytokine. Alternate names include IL18BPa, IL18BPb, and IL18BPc, reflecting the multiple isoforms generated by alternative splicing. IL18BP neutralizes IL18 by binding with high affinity, preventing its interaction with the IL18 receptor and subsequent activation of NF kappa B and interferon gamma pathways.

IL18BP antibody is widely applied in immunology, inflammation research, and translational medicine. By detecting IL18BP, researchers can investigate how immune regulation balances inflammatory cytokine activity. Overexpression of IL18BP provides protection from excessive inflammation, while deficiency or altered expression contributes to autoimmune disorders and infectious disease susceptibility.

ELISA detects IL18BP in serum and culture supernatants, while western blotting identifies isoform expression. Immunohistochemistry maps IL18BP production in tissues undergoing immune activation. These methods make IL18BP antibody useful for evaluating cytokine regulation in health and disease.

IL18BP has therapeutic potential as a biologic agent. Recombinant IL18BP has been developed to treat inflammatory diseases such as adult onset Still disease and hemophagocytic lymphohistiocytosis. By applying IL18BP antibody, researchers can monitor therapeutic levels and investigate how modulation of IL18 signaling influences disease outcomes.

IL18BP antibody from NSJ Bioreagents delivers dependable specificity for analyzing interleukin 18 binding protein. Its reliable performance across assays ensures accurate detection of this immune regulator.

UniProt: O95998