INSIG1 Antikörper
Kurzübersicht für INSIG1 Antikörper (ABIN7881180)
Target
Alle INSIG1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- Insig1 Antibody / Insulin-induced gene 1
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Sequenz
- MPRLHDHVWS YPSA
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Aufreinigung
- Affinity purified
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Immunogen
- Amino acids MPRLHDHVWSYPSA from the rat protein were used as the immunogen for the Insig1 antibody.
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Isotyp
- IgG
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anti-Insulin Induced Gene 1 (INSIG1) (Internal Region) antibody
INSIG1 Reaktivität: Human, Maus WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 1-87) antibodyINSIG1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 36-63), (N-Term) antibodyINSIG1 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB21689 unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 63-112) antibodyINSIG1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Hund, Meerschweinchen, Schwein, Affe, Hamster, Xenopus laevis, Fledermaus, Huhn WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Hund, Meerschweinchen, Schaf, Zebrafisch (Danio rerio) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 71-120) antibodyINSIG1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Schaf, Schwein, Hamster, Xenopus laevis WB Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (C-Term) antibodyINSIG1 Reaktivität: Human, Affe WB Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Hund, Meerschweinchen, Schaf, Schwein, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- Optimal dilution of the Insig1 antibody should be determined by the researcher.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- After reconstitution, the Insig1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- INSIG1 (Insulin Induced Gene 1 (INSIG1))
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Andere Bezeichnung
- Insig1
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Hintergrund
- Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene. This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.
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UniProt
- Q08755
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Pathways
- ER-Nucleus Signaling
Target
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