Rekombinanter HNRNPM Antikörper

Produktnummer ABIN7881033

Der Kaninchen Monoklonal anti-HNRNPM Antikörper wird verwendet zum Nachweis von HNRNPM in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC, IF, ICC und FACS.

Kurzübersicht für Rekombinanter HNRNPM Antikörper (ABIN7881033)

Target: HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M (HNRNPM))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser HNRNPM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 29H77

Produktdetails anti-HNRNPM Antikörper

Verwendungszweck: HNRNPM Antibody / heterogeneous nuclear ribonucleoprotein M

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human HNRNPM was used as the immunogen for the HNRNPM antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the HNRNPM antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the HNRNPM antibody at -20oC.

Details zu HNRNPM

Target: HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M (HNRNPM))

Andere Bezeichnung: HNRNPM

Hintergrund: HNRNPM antibody recognizes heterogeneous nuclear ribonucleoprotein M, an RNA-binding protein involved in pre-mRNA processing and splicing regulation. HNRNPM is part of the hnRNP family, which associates with nascent transcripts to influence alternative splicing, stability, transport, and translation. This protein is widely expressed and contributes to the regulation of diverse gene expression programs in normal development and stress adaptation.

Research using HNRNPM antibody has linked the protein to cancer progression and metastasis. By regulating alternative splicing of genes related to epithelial-to-mesenchymal transition (EMT), HNRNPM promotes tumor invasiveness and metastatic potential. Elevated expression of HNRNPM has been associated with poor prognosis in breast, colorectal, and liver cancers. Its role in RNA processing makes it a critical factor in understanding how splicing dysregulation contributes to oncogenesis.

Beyond cancer, HNRNPM has been implicated in immune function and neurobiology. Studies suggest roles in regulating splicing of immune-related transcripts and neuronal genes, connecting HNRNPM to autoimmune conditions and neurological disorders. Its widespread impact on RNA metabolism positions HNRNPM as an important regulator of cellular identity and function.

Antibodies against HNRNPM are validated for western blot, immunoprecipitation, immunohistochemistry, and immunofluorescence. Researchers use these reagents to analyze HNRNPM expression, splicing complex assembly, and transcript-specific binding. Clone-based antibodies offer the specificity needed to study this protein within large multi-protein RNA processing complexes.

NSJ Bioreagents offers this HNRNPM antibody for investigations into RNA splicing, cancer biology, and immune regulation.

UniProt: P52272