HES5 Antikörper

Produktnummer ABIN7880953

Der Maus Monoklonal anti-HES5 Antikörper (Klon HES5-8035) (ABIN7880953) detektiert spezifisch HES5 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für HES5 Antikörper (ABIN7880953)

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HES5 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: HES5-8035

Produktdetails anti-HES5 Antikörper

Verwendungszweck: HES5 Antibody / BHLHB38 (azide and preservative free)

Aufreinigung: Protein G affinity

Immunogen: A recombinant partial protein from human HES5 protein was used as the immunogen for the HES5 antibody.

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the HES5 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the HES5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu HES5

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Andere Bezeichnung: HES5

Hintergrund: The Drosophila Hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila Hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

UniProt: Q5TA89

Pathways: Stem Cell Maintenance, Tube Formation