GRID2 Antikörper

Produktnummer ABIN7880884

Der Kaninchen Polyklonal anti-GRID2 Antikörper (ABIN7880884) detektiert spezifisch GRID2 in WB, FACS und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für GRID2 Antikörper (ABIN7880884)

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRID2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GRID2 Antikörper

Verwendungszweck: GRID2 Antibody

Sequenz: KKDDEVFRTA VGDLNQN

Aufreinigung: Affinity purified

Immunogen: Amino acids KKDDEVFRTAVGDLNQN from the human protein were used as the immunogen for the GRID2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GRID2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GRID2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GRID2

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Andere Bezeichnung: GRID2

Hintergrund: Glutamate receptor, ionotropic, delta 2, also known as GluD2 and GluR delta 2, is a protein that in humans is encoded by the GRID2 gene. The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

UniProt: O43424

Pathways: Synaptic Membrane