GRID2 Antikörper (AA 800-880)

Produktnummer ABIN7221306

Der Kaninchen Polyklonal anti-GRID2 Antikörper wird verwendet zum Nachweis von GRID2 in Proben von Human, Ratte und Maus. Er wurde validiert für WB, IF und ELISA.

Kurzübersicht für GRID2 Antikörper (AA 800-880) (ABIN7221306)

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRID2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA

Produktdetails anti-GRID2 Antikörper

Bindungsspezifität: AA 800-880

Verwendungszweck: Rabbit Anti-GluR-δ2 Polyclonal Antibody

Spezifität: GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human GluR-delta2 at AA range: 800-880

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu GRID2

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Andere Bezeichnung: GluR-delta2

Hintergrund: GRID2, GLURD2, Glutamate receptor delta-2 subunit, GluR delta-2 subunitThe glutamate ionotropic receptor delta type subunit 2 encoded by GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

Molekulargewicht: 113kD

Gen-ID: 2895

UniProt: O43424

Pathways: Synaptic Membrane