ERCC1 Antikörper

Produktnummer ABIN7880754

Der Kaninchen Monoklonal anti-ERCC1 Antikörper wird verwendet zum Nachweis von ERCC1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für ERCC1 Antikörper (ABIN7880754)

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser ERCC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: AOFA-5

Produktdetails anti-ERCC1 Antikörper

Verwendungszweck: ERCC1 Antibody

Aufreinigung: Affinity purified

Immunogen: A synthetic peptide specific to human ERCC1 was used as the immunogen for the ERCC1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ERCC1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the ERCC1 antibody at -20oC.

Details zu ERCC1

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Andere Bezeichnung: ERCC1

Hintergrund: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. [RefSeq]

UniProt: P07992

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response