Der Kaninchen Monoklonal anti-Desmoglein 1 Antikörper (Klon DSG1-8576R) (ABIN7880623) detektiert spezifisch Desmoglein 1 in IHC (p).
Dieser Antikörper reagiert spezifisch mit Proben aus Human.
Verified
DSG1
Reaktivität: Human
IHC, ELISA
Wirt: Ziege
Polyclonal
unconjugated
Applikationshinweise
Optimal dilution of the Desmoglein 1 antibody should be determined by the researcher.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.2 mg/mL
Buffer
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the Desmoglein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Target
Desmoglein 1 (DSG1)
Andere Bezeichnung
Desmoglein 1
Hintergrund
Recognizes a protein of ~150 kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.