Rekombinanter Desmoglein 1 Antikörper
Kurzübersicht für Rekombinanter Desmoglein 1 Antikörper (ABIN7880623)
Target
Alle Desmoglein 1 (DSG1) Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Desmoglein 1 Antibody / DSG1
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Aufreinigung
- Protein A/G affinity
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Immunogen
- Recombinant human DSG1 protein was used as the immunogen for the Desmoglein 1 antibody.
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Isotyp
- IgG, kappa
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Applikationshinweise
- Optimal dilution of the Desmoglein 1 antibody should be determined by the researcher.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 0.2 mg/mL
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Buffer
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the Desmoglein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Desmoglein 1 (DSG1)
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Andere Bezeichnung
- Desmoglein 1
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Hintergrund
- Recognizes a protein of ~150 kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
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UniProt
- Q02413
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Pathways
- Cell-Cell Junction Organization
Target
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