Desmoglein 1 Antikörper

Produktnummer ABIN7880621

Dieser Maus Monoklonal Antikörper detektiert spezifisch Desmoglein 1 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Desmoglein 1 Antikörper (ABIN7880621)

Target: Desmoglein 1 (DSG1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Desmoglein 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 32-2B

Produktdetails anti-Desmoglein 1 Antikörper

Verwendungszweck: Desmoglein 1 Antibody / DSG1

Aufreinigung: Protein G affinity chromatography

Immunogen: Bovine desmoglein (desmosomal glyco protein I) from nasal epidermis was used as the immunogen for the Desmoglein 1 antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Desmoglein 1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Desmoglein 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Desmoglein 1

Target: Desmoglein 1 (DSG1)

Andere Bezeichnung: Desmoglein 1

Hintergrund: Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

UniProt: Q02413

Pathways: Cell-Cell Junction Organization