Rekombinanter Desmocollin 1 Antikörper

Produktnummer ABIN7880619

Der Kaninchen Monoklonal anti-Desmocollin 1 Antikörper wird verwendet zum Nachweis von Desmocollin 1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für Rekombinanter Desmocollin 1 Antikörper (ABIN7880619)

Target: Desmocollin 1 (DSC1)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Desmocollin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 31D56

Produktdetails anti-Desmocollin 1 Antikörper

Verwendungszweck: DSC1 Antibody / Desmocollin 1

Aufreinigung: Affinity chromatography

Immunogen: A synthesized peptide derived from human Desmocollin 1 was used as the immunogen for the DSC1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the DSC1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the DSC1 antibody at -20oC.

Details zu Desmocollin 1

Target: Desmocollin 1 (DSC1)

Andere Bezeichnung: DSC1

Hintergrund: DSC1 antibody detects Desmocollin 1, encoded by the DSC1 gene. Desmocollin 1 is a calcium-dependent glycoprotein and a member of the cadherin superfamily that forms part of desmosomes, specialized structures mediating cell-cell adhesion in epithelial tissues. DSC1 antibody provides researchers with an important reagent for studying adhesion, epidermal integrity, and disease processes involving skin and epithelial biology.

Desmocollin 1 is a transmembrane protein that interacts with desmogleins, plakoglobin, and desmoplakin to form stable desmosomal junctions. Research using DSC1 antibody has shown that it is expressed predominantly in stratified squamous epithelia, where it contributes to strong intercellular adhesion. This adhesion maintains tissue integrity under mechanical stress, particularly in the skin and mucosal surfaces.

Studies with DSC1 antibody have revealed that Desmocollin 1 exists in multiple isoforms generated by alternative splicing. These isoforms contribute to structural diversity within desmosomes and enable fine-tuning of adhesive strength. Regulation of isoform expression is developmentally controlled and varies between epithelial layers, suggesting specialized functions for different Desmocollin 1 variants.

Dysregulation of Desmocollin 1 is linked to disease. Research using DSC1 antibody has demonstrated that mutations in DSC1 cause striate palmoplantar keratoderma, a skin disorder characterized by thickening of the palms and soles. Autoantibodies against Desmocollin 1 are found in autoimmune skin diseases such as pemphigus. Loss of Desmocollin 1 expression has also been reported in cancers, where reduced adhesion facilitates invasion and metastasis. These findings highlight the importance of DSC1 in health and disease.

Desmocollin 1 also contributes to barrier function. Studies with DSC1 antibody have shown that intact desmosomal adhesion prevents pathogen invasion and regulates paracellular permeability. This function underscores the role of Desmocollin 1 not only in mechanical integrity but also in defense and tissue homeostasis.

DSC1 antibody is commonly applied in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry highlights localization in epithelial layers, immunofluorescence reveals colocalization with other desmosomal proteins at junctions, and western blotting detects isoform expression. These applications make DSC1 antibody essential for adhesion biology and pathology research.

By providing validated DSC1 antibody reagents, NSJ Bioreagents supports studies into epithelial adhesion, skin disease, and cancer. Detection of Desmocollin 1 provides insight into how desmosomal proteins maintain tissue structure and how their disruption leads to disease.

UniProt: Q08554