Rekombinanter C1QA Antikörper

Produktnummer ABIN7880493

Der Kaninchen Monoklonal anti-C1QA Antikörper wird verwendet zum Nachweis von C1QA in Proben von Human und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für Rekombinanter C1QA Antikörper (ABIN7880493)

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser C1QA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: 31C57

Produktdetails anti-C1QA Antikörper

Verwendungszweck: C1QA Antibody / Complement component 1 subcomponent subunit A

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human C1QA was used as the immunogen for the C1QA antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the C1QA antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the C1QA antibody at -20oC.

Details zu C1QA

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Andere Bezeichnung: C1QA

Hintergrund: C1QA antibody detects complement component 1 subcomponent subunit A, encoded by the C1QA gene. C1QA is one of three chains (A, B, and C) that assemble to form the C1q protein complex, a recognition unit of the classical complement pathway. C1q binds to antibodies or immune complexes, initiating complement activation and promoting clearance of pathogens and apoptotic cells. Through these roles, C1QA is central to innate immunity and host defense.

C1QA antibody is commonly used in immunology, inflammation, and autoimmune disease research. C1QA expression is highest in monocytes, macrophages, and dendritic cells. It functions as a pattern recognition receptor that bridges innate and adaptive immunity. By detecting C1QA, researchers can study activation of complement pathways and regulation of immune responses.

In western blot assays, C1QA antibody detects protein bands of expected size in immune cell extracts. Immunohistochemistry highlights strong expression in macrophages and tissue resident immune cells. Immunofluorescence enables visualization of C1QA in immune synapses and complement activation sites. ELISA supports quantification of circulating C1QA in biological samples.

Deficiency of C1QA is associated with autoimmune disorders such as systemic lupus erythematosus, underscoring its importance in self tolerance and immune clearance. Elevated expression of C1QA has been linked to chronic inflammation and neurodegenerative diseases, including Alzheimer disease, where complement activation contributes to pathology. By applying C1QA antibody, scientists can investigate how alterations in complement regulation affect health and disease.

C1QA antibody from NSJ Bioreagents offers reliable specificity for complement research. Its performance across methods ensures accurate detection of this key immune recognition protein.

UniProt: P02745

Pathways: Komplementsystem