Rekombinanter CLIC4 Antikörper

Produktnummer ABIN7880409

Der Kaninchen Monoklonal anti-CLIC4 Antikörper wird verwendet zum Nachweis von CLIC4 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC, ICC, IF, IP und FACS.

Kurzübersicht für Rekombinanter CLIC4 Antikörper (ABIN7880409)

Target: CLIC4 (Chloride Intracellular Channel 4 (CLIC4))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CLIC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS)

Klon: 30C24

Produktdetails anti-CLIC4 Antikörper

Verwendungszweck: CLIC4 Antibody / Chloride intracellular channel protein 4

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CLIC4 was used as the immunogen for the CLIC4 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CLIC4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the CLIC4 antibody at -20oC.

Details zu CLIC4

Target: CLIC4 (Chloride Intracellular Channel 4 (CLIC4))

Andere Bezeichnung: CLIC4

Hintergrund: CLIC4 antibody targets chloride intracellular channel protein 4, a member of the CLIC family of proteins that function as intracellular chloride channels and signaling modulators. Unlike classical ion channels, CLIC4 can exist in both soluble and membrane-associated forms, transitioning between states to regulate chloride conductance. This protein is expressed across many tissues, including endothelial cells, immune cells, and epithelial cells, where it contributes to processes such as apoptosis, angiogenesis, and cellular stress responses.

Research using CLIC4 antibody has demonstrated its involvement in multiple pathological processes. CLIC4 is frequently upregulated during tissue remodeling and fibrotic diseases, where it influences transforming growth factor-beta (TGF-beta) signaling pathways. It has also been studied in the context of cancer, with evidence suggesting that CLIC4 contributes to tumor progression and metastasis through regulation of cell migration and invasion. In immune biology, CLIC4 has been implicated in the modulation of macrophage activation and inflammatory responses.

Validated clones for CLIC4 detection perform well in assays including western blot, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to monitor subcellular localization, expression changes under stress conditions, and signaling outcomes tied to chloride channel activity. The versatility of CLIC4 in both membrane transport and cell signaling makes it a protein of interest in diverse fields of study.

NSJ Bioreagents offers this CLIC4 antibody to support investigations in cancer biology, fibrosis, and cellular signaling. Alternate names include chloride intracellular channel protein 4 antibody, CLIC4A antibody, MSTP046 antibody, HuH1 antibody, and DKFZp564F012 antibody.

UniProt: Q9Y696