BNIP3L/NIX Antikörper

Produktnummer ABIN7880065

Der Kaninchen Monoklonal anti-BNIP3L/NIX Antikörper (Klon ABIB-2) (ABIN7880065) detektiert spezifisch BNIP3L/NIX in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für BNIP3L/NIX Antikörper (ABIN7880065)

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser BNIP3L/NIX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: ABIB-2

Produktdetails anti-BNIP3L/NIX Antikörper

Verwendungszweck: Nix Antibody / BNIP3L

Aufreinigung: Affinity purified

Immunogen: A synthetic peptide specific to human Nix / BNIP3L was used as the immunogen for the Nix antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Nix antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the Nix antibody at -20oC.

Details zu BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Andere Bezeichnung: Nix

Hintergrund: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like' (BNIP3L), also called NIP3-like protein X (Nix) induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. [UniProt]

UniProt: O60238

Pathways: Autophagie