PUMA Antikörper

Produktnummer ABIN7880054

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PUMA in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PUMA Antikörper (ABIN7880054)

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PUMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PUMA Antikörper

Verwendungszweck: PUMA Antibody (alpha/beta) / BBC3

Sequenz: EQWAREIGAQ LRRMADDLNA QYE

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids EQWAREIGAQLRRMADDLNAQYE were used as the immunogen for the PUMA antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PUMA antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PUMA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PUMA

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Andere Bezeichnung: PUMA

Hintergrund: Bcl-2-binding component 3, isoforms 1/2 (BBC3), also called p53 upregulated modulator of apoptosis (PUMA), is a pro-apoptotic member of the Bcl-2 protein family. The gene is located at 19q. The transcript is contained within 4 exons, with the presumptive initiation codon in exon 2. The predicted 193-amino acid PUMA protein shares 91 % amino acid identity with the murine sequence. Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and the protein has been shown to be involved in p53-mediated apoptosis. Additionally, PUMA encodes two BH3 domain-containing proteins, PUMA-alpha and PUMA-beta, that are produced through the use of an alternative first exon and are induced in cells following p53 activation. Furthermore, PUMA couples the nuclear and cytoplasmic proapoptotic functions of p53.

UniProt: Q9BXH1

Pathways: p53 Signalweg, Positive Regulation of Endopeptidase Activity