Annexin A2 Antikörper (N-Term)

Produktnummer ABIN7879560

Der Kaninchen Polyklonal anti-Annexin A2 Antikörper wird verwendet zum Nachweis von Annexin A2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und FACS.

Kurzübersicht für Annexin A2 Antikörper (N-Term) (ABIN7879560)

Target: Annexin A2 (ANXA2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Annexin A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-Annexin A2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: ANXA2 Antibody / Annexin A2

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human ANXA2 was used as the immunogen for the ANXA2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ANXA2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ANXA2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Annexin A2

Target: Annexin A2 (ANXA2)

Andere Bezeichnung: ANXA2

Hintergrund: ANXA2 antibody detects Annexin A2, a calcium-dependent phospholipid-binding protein involved in membrane organization, cytoskeletal interactions, and fibrinolysis. Encoded by the ANXA2 gene on chromosome 15q26.1, this multifunctional protein participates in membrane trafficking, endocytosis, cell-cell adhesion, and extracellular matrix remodeling. Annexin A2 also acts as a cell surface receptor for tissue plasminogen activator (tPA) and plasminogen, facilitating localized fibrin degradation and vascular repair.

Structurally, Annexin A2 is a 339-amino-acid protein of approximately 39 kilodaltons containing four annexin repeats that mediate calcium-dependent phospholipid binding and a unique N-terminal domain that interacts with S100A10 (p11) to form a heterotetrameric complex. This complex localizes to the plasma membrane, cytoskeleton, and endosomal compartments, where it modulates vesicle fusion, cytoskeletal anchoring, and membrane curvature. Annexin A2 is expressed in endothelial, epithelial, and tumor cells, as well as macrophages and neurons.

The ANXA2 antibody is widely used in cell biology, vascular biology, and cancer research to study membrane organization, signal transduction, and fibrinolytic regulation. Western blot analysis detects a 39 kilodalton band corresponding to Annexin A2, while immunofluorescence shows cytoplasmic, membrane, and perinuclear localization. This antibody provides a powerful reagent for investigating calcium-dependent membrane remodeling and extracellular proteolytic activity.

Functionally, Annexin A2 regulates actin cytoskeleton rearrangement and vesicle trafficking, influencing endocytosis, exocytosis, and cell motility. At the cell surface, it promotes plasmin generation, contributing to fibrin degradation, angiogenesis, and tumor invasion. Dysregulation of ANXA2 expression is associated with cancer progression, thrombosis, and inflammatory disease. The ANXA2 antibody supports detailed studies of its role in cellular dynamics, extracellular matrix remodeling, and vascular homeostasis. NSJ Bioreagents validates this antibody for its applications, ensuring precise detection in studies of cytoskeletal and membrane biology.

UniProt: P07355

Pathways: S100 Proteine