Histone H2A Antikörper (H2AS139ph)

Produktnummer ABIN7879416

Der Maus Monoklonal anti-Histone H2A Antikörper wird verwendet zum Nachweis von Histone H2A in Proben von Human und Maus. Er wurde validiert für WB und IF.

Kurzübersicht für Histone H2A Antikörper (H2AS139ph) (ABIN7879416)

Target: Histone H2A

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Histone H2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Histone H2A Antikörper

Bindungsspezifität: H2AS139ph

Verwendungszweck: Phospho-Histone H2AX Antibody (pS139)

Aufreinigung: Antigen affinity purified

Immunogen: The amino acid sequence surrounding phosphorylated serine 139 was used as the immunogen for the Phospho-Histone H2AX antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Titration of the Phospho-Histone H2AX antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Phospho-Histone H2AX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Histone H2A

Target: Histone H2A

Hintergrund: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

UniProt: P16104